THE ANALYSIS OF SOCIAL AND GENETIC RELATIONSHIP CHANGES AMONG BURU COMMUNITY FROM CONTEMPORARY PERSPECTIVE





Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Abstract Background Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways.Recent data have shown that MPL function is essential for CALR mutant-driven MPN.However, the exact role

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